Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity
In this study, synthetic vaccine nanoparticles (SVNPs) that efficiently targeted lymph nodes,
where immune responses against foreign antigens are primed, were developed to enhance
antitumor immunity. The size (20–70 nm) and surface character (amination) of poly (γ-
glutamic acid)-based SVNPs were selected for effective loading and delivery (ie., migration
and retention) of model tumor antigen (OVA) and toll-like receptor 3 agonist (poly (I: C)) to
immune cells in lymph nodes. Antigen-presenting cells treated with SVNP-OVA and SVNP …
where immune responses against foreign antigens are primed, were developed to enhance
antitumor immunity. The size (20–70 nm) and surface character (amination) of poly (γ-
glutamic acid)-based SVNPs were selected for effective loading and delivery (ie., migration
and retention) of model tumor antigen (OVA) and toll-like receptor 3 agonist (poly (I: C)) to
immune cells in lymph nodes. Antigen-presenting cells treated with SVNP-OVA and SVNP …
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